Influence of Probiotics Supplementation on the Lipid Profile of Hypercholesterolemic Rats
Keywords:
probiotics, cholesterol, blood lipids
Abstract
Accelerating growth of the evidences refers that dietary supplementation with probiotic bacteria in fermented milk improves the lipid profile. Two genera of probiotics bacteria as bio-starters at the level of "107 CFU/ml" in fermented milk (Lactobacillus and Bifidobacterium) were used to examine their beneficial effect on the lipid profile of hypercholesterolemic rats which were administered for feeding on high cholesterol diet for two months. Significant going down of the serum total cholesterol (TC), triacylglycerol (TG), low-density lipoprotein (LDL)-cholesterol levels, and very low-density lipoprotein (VLDL)-cholesterol levels, but scale-up of high-density lipoprotein (HDL)-cholesterol were noticed after dietary supplement with probiotic bacteria in hypercholesterolemic rats. Hence, this indicates to the useful of fermented milk for improving the prevention of cardiovascular disease.
References
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2. AHA/ACC: Key data elements and definition for coronary revascularization, medical guidelines and scientific statements. National Center, Dallas, TX, US. 2020.
3. Artham, S.M.; Lavie, C.J.; Milani, R.V.; Ventura, H.O.: The obesity paradox: Impact of obesity on the prevalence and prognosis of cardiovascular diseases. Post grad. Med. 2008, 120, 34–41. [CrossRef] [PubMed]
4. Davis, C.E.; Rifkind, B.M.; Brenner, H.; Gordon, D.J.: A single cholesterol measurement underestimates the risk of coronary heart disease. An empirical example from the Lipid Research Clinics Mortality Follow-up Study. JAMA. 1990, 264, 3044–3046. [CrossRef] [PubMed]
5. De Vrese M. and Schrezenmeir J.: Probiotics, prebiotics, and synbiotics. Adv Biochem Eng Biotechnol. 2008, 111: 1-66.
6. FAO/WHO "Food and Agriculture Organization / World Health Organization": Evaluation of Health and Nutritional Properties of Powder Milk and Live Lactic Acid Bacteria; Food and Agriculture Organization of the United Nations and World Health Organization Expert Consultation Report; FAO/WHO: 2001. Rome, Italy.
7. Friedewald, W.T., Levy, R.I. and Fredrickson, D.S: Estimation of concentration of LDL-cholesterol in plasma, without use of preparative ultracentrifuge. Clinical Chem. 1972, 18: 499-502.
8. Jesús Millán, Xavier Pintó, Anna Muñoz, Manuel Zúñiga, Joan Rubiés-Prat, Luis Felipe Pallardo, Luis Masana, Alipio Mangas, Antonio Hernández-Mijares, Pedro González-Santos, Juan F Ascaso, and Juan Pedro-Botet: Lipoprotein ratios: Physiological significance and clinical usefulness in cardiovascular prevention. Vasc Health Risk Manag. 2009, 5: 757-765.
9. Park, YH; Kim, JG; Shin, YW; Kim, SH. and Whang, KY.: Effect of dietary inclusion of Lactobacillus acidophilus ATCC 43121 on cholesterol metabolism in rats. J Microbiol Biotechnol. 2007, Vol. 17, No.4, 655-62.
10. Pereira D.I. and Gibson G.R.: Effect of consumption of probiotics and prebiotics on serum lipid levels in humans. Crit Rev Biol. 2002, vol.37, No 4, 259-81.
11. Reeves PG, Nielsen FH, Fahey GC.: AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr. 1993, 123:1939–51.
12. SAS: Statistical Analysis System, User guide: statistics. SAS Institute Inc. Editors, Cary, NC. 1996.
13. Sanders M.E.: Probiotics: definition, sources, selection, and uses. Clin Infect Dis. 2008, 1; 46, Supp 12, 58-61.
14. Xiao, J.Z.; Kondo, S.; Takahashi, N.; Miyaji, K.; Oshida, K.; Hiramatsu, A.; Iwatsuki, K.; Kokubo, S.; Hosono, A.: Effects of milk products fermented by Bifidobacterium longum on blood lipids in rats and healthy adult male volunteers. J. Dairy Sci. 2003, 86, 2452–2461. [CrossRef]
15. Zulet, MA; Barber, A; Garcin, H; Higueret, P. and Martinez, A.: Alterations in carbohydrate and lipid metabolism induced by a diet rich in coconut oil and cholesterol in a rat model. J. AM. Coll. Nutr.1999, Vol. 18, No. 1, 36-42.
Published
2020-07-05
How to Cite
Dr. Amal Mohammed Allbban. (2020). Influence of Probiotics Supplementation on the Lipid Profile of Hypercholesterolemic Rats. Journal of Arts, Literature, Humanities and Social Sciences, (54), 379-386. https://doi.org/10.33193/JALHSS.54.2020.145
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